Discovery / Research

Veterinary Pathologist Direct Hire MA

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Job ID: 16052 Direct Hire MA

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Our client is a medical device and pharmaceutical Contract Research Organization in the suburbs of Boston.  They are seeking a Veterinary Pathologist to join their Pathology team and work with clients to design studies, analyze and present data internally and to the study sponsors, and support implementation & optimization of adjunct technologies and services (fluorescent microscopy, in-house clinical pathology and clinical chemistry).

Responsibilities include but are not limited to;
•  Function as Study Director or Principal Investigator, as required, and communicate with study sponsors to design studies and report pathological and/or study related findings
•  Evaluation of tissue responses via gross inspection and microscopy and supervising necropsy procedures
•  Peer review of pathology working group and serve as a consultant in pathology-related issues 

Formal descriptions can be supplied for interested candidates. 

Qualified candidates will have a DVM or equivalent degree and ACVP certification. Industry experience is not required but welcome.  More experienced candidates are also welcome.  

Must be authorized to work in the US indefinitely to be considered and must be commutable to the suburbs of Boston/Cambridge area or able to relocate with limited assistance.  

All resumes will be kept strictly confidential until you choose to pursue a specific opportunity with one of our clients.

Scientist I/II, Bioanalytical Development Direct Hire MA

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Job ID: 15996 Direct Hire MA

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Our client is a public, mid-sized therapeutics company based in Cambridge with approved products already on market and a strong pipeline.  They are seeking an experienced Bioanalytical Scientist to join their Drug Discovery team to support non-clinical and discovery stage programs.      

The main function of this role is to develop and validate bioanalytical/analytical methods in support of the company's pipeline covering both preclinical and clinical studies. You will have the opportunity to work with the nonclinical team and manage CRO partnerships to ensure assays are well qualified/validated. 

Responsibilities include but are not limited to;
•  Development and validation of bioanalytical LC/MS methods for discovery non-GLP pharmacokinetic/pharmacodynamic studies, GLP toxicology studies and clinical studies.
•  Effectively collaborate with bioanalytical/analytical CROs to support GLP toxicology and clinical phase studies.
•  Review and finalization of method validation and bioanalytical reports.

Formal descriptions can be supplied for interested candidates. 

Qualified candidates will have a PhD in a Biology, Chemistry, or a related Life Sciences and 2-5+ years of experience (or a MS and 10+ years) in method development and validation of LC/MS-based assays.  Experience monitoring and managing external work at CROs is required.

Must be authorized to work in the US indefinitely to be considered and must be commutable to the Cambridge area or able to relocate with limited assistance.  

All resumes will be kept strictly confidential until you choose to pursue a specific opportunity with one of our clients.

Principal Computational Scientist Direct Hire MA

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Job ID: 15995 Direct Hire MA

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Our Global Biologics client is looking to add a Principal Computational Scientist to their team to support their Immuno-Oncology programs here in Cambridge, MA!  It is an exciting time to be a part of the Discovery teams!  This role will help with designing experiments, manage data, and use advanced statistical, machine learning, as well as computational techniques to discover new targets either to stop the growth of cancer or re-awaken the immune system to eradicate the cancer. Furthermore, the Data Scientist will collaborate with Early Development teams to guide the development of molecules against those targets with data-driven biomarker plans.  Other responsibilities include but not limited to:

  • Work with project teams to define scientific questions that can be addressed with an appropriately powered experimental designs
  • Supply any computational, statistical, machine learning, or modeling capability needed to synthesize from this design actionable recommendations relative to the team’s question
  • In collaboration with project teams, propose analysis strategies for target discovery, using methods based for instance on differential expression, co-regulation, correlated amplification, recurrent alterations, etc.; in so doing, also help devise statistical metrics for deciding significance, and ranking schemes for integrating data from many sources
  • Identify targets and biological contexts (e.g., T or B-cell repertoire, immune phenotypes, copy number, mutational, or expression signatures) in which therapies are likely to be beneficial by mining immune, genetic, genomic or screening data
  • Identify from patient and model system databases the epidemiology of these biological contexts and targets
  • Develop biomarker plans (e.g., selection, PD, efficacy) in collaboration with project teams
  • Manage and develop group of one or more associates and/ or contractors

Requirements:

  • Ph.D. in a computational, statistical, biophysics, or bioinformatics related fields.
  • A minimum of 8+ years project-based work in computational application to biology related fields, preferably Immuno-Oncology
  • Statistical programming skills like SAS/S-plus, R/Bioconductor and pipeline pilot or equivalents
  • Excellent understanding of immunology and hands-on research experience investigating complex lymphoid and/or myeloid cell subsets
  • First-hand multi-parametric data mining experience for target identification and biomarker discovery. For example, multivariate analysis; dimensionality reduction methods; parametric and non-parametric statistical methods; Bayesian statistics; pattern recognition or classification methods.
  • First-hand experience at integrating publicly or commercially available genetic, genomic, and immune datasets with novel experimental data to identify testable hypotheses
  • Developed communication and presentation skills and a successful track record of collaborating with cross-functional project teams
  • Demonstrated ability to lead projects of moderate scope, mapping-out critical path, milestones and timelines, as well as manage customer expectations with minimal supervision

Sr. Research Associate, Immunology Direct Hire MA

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Job ID: 15989 Direct Hire MA

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Our growing Cambridge, MA client is looking to add Scientist /Sr. Scientist, Protein Design to their team to help discover new antibody discovery platforms within the cancer immunotherapy space! Their mission is to develop best-in-class multi-specific and multi-functional immunotherapies, to enable patients to harness their own body to fight cancer. Responsibilities include but not limited to:

  • Develop and perform in vitro translational assays using human and murine immune cells with a higher degree of complexity and minimum supervision
  • Document all data and maintains high quality lab notebooks. Able to contribute to technical reports and patent/regulatory filings
  • May mentor peers and fill in for supervisor on lab related decisions

Requirements:

  • B.S. or M.S., with 3 or more years of industry working experience in the field of immunology
  • Demonstrated ability to independently conceive, execute, and interpret a complete range of experiments, as well as work effectively as a team member, contributing to discussions around own expertise while showing an understanding of the role of the other members
  • Experience in FACS analyses (multi-parameter, intracellular cytokine staining), familiarity with Flowjo program, cytokine analysis by ELISA, and multiplex assays (MDS or Luminex)
  • Experience in immune cell isolation of human and rodent original (e.g. density centrifugation, magnetic bead separation)

Sr. Toxicologist for clinical-stage biotech Direct Hire Massachusetts

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Job ID: 15758 Direct Hire Massachusetts

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Our well-funded Cambridge start-up client is seeking an experienced Toxicologist to lead pipeline projects by directing GLP & non-GLP studies with CROs and participating in Regulatory filings.  You will work closely with program leaders, clinical and regulatory teams to develop an overall toxicology development plan including lead optimization, candidate selection, IND-enabling studies, etc.

Responsibilities include but are not limited to;
•  Interact with CROs for quotes, cost estimates, and monitor study activities including protocol development and report generation.  
•  Provide strategic advice to senior leadership and relevant project teams regarding potential impact of study results on program and clinical/regulatory strategy.
•  Communicating with regulatory bodies in support of global regulatory submissions.

Formal descriptions can be supplied for interested candidates. 

Qualified candidates will have a Ph.D. in Toxicology or relevant field with a minimum of 3 - 5+ years of experience in nonclinical development and conducting regulatory toxicology studies.  More experienced candidates can also be considered.  Candidates who have DABT certification are welcome but it is not required to be considered.  Candidates must have experience in various aspects of toxicology study conduct including developmental and reproductive toxicology, carcinogenicity, toxicokinetics, and safety pharmacology as well as experience in designing, conducting, monitoring, and interpreting discovery and exploratory toxicology studies to assist lead optimization and candidate selection efforts.  Must also have experience in management of external CROs and representing Toxicology function to global regulatory agencies in support of submissions.  

All resumes will be kept strictly confidential until you choose to pursue a specific opportunity with one of our clients.

Associate Scientist, CAR-T Direct Hire MA

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Job ID: 15365 Direct Hire MA

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Our client is a highly-regarded cell/gene therapy company in the greater Boston area and they are seeking an experienced, highly-motivated Immuno-Oncology Associate Scientist to join their research and discovery team to work on next-generation CAR-T therapies in oncology! You will collaborate with and help other teammates troubleshoot assays, as well as identify and develop new targets and chimeric antigen receptors (CARs). The main function of this role is to support cell-based assays for T cell characterization, proliferation, and function, and to coordinate new research projects to overcome various obstacles within the tumor microenvironment.

Responsibilities:
•  Support diverse immunological assays to evaluate T-cell biology, including cell sorting (fluorescent and/or magnetic), multi-color flow cytometry, Luminex, cytokine profiling, etc.
•  Analyze experimental and flow cytometry data to identify promising new CAR candidates for subsequent development.
•  Work collaboratively/cross-functionally and use viral vectors to genetically modify T lymphocytes.?

Requirements:

•  BS/MS in Immunology, Cell/Molecular Biology, or related field.
•  At least 2+ years of relevant experience in immunology, I/O, or cancer biology.
•  Experience with cell culture techniques, sorting primary human and/or animal T cells, and developing cell-based immuno-assays and T cell functional assays.
•  Applied expertise in T cell therapeutics is a plus, especially in industry.

Formal descriptions can be supplied for interested candidates.

Must be authorized to work in the U.S. indefinitely to be considered.

All resumes will be kept strictly confidential until you choose to pursue a specific opportunity with one of our clients.

CAR-T Scientist Direct Hire MA

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Job ID: 15301 Direct Hire MA

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Our client is a highly-regarded cell/gene therapy company in the greater Boston area and they are seeking an experienced, highly-motivated Immuno-Oncology Scientist to join their research and discovery team to work on next-generation CAR-T therapies in oncology! You will collaborate with and help other teammates troubleshoot assays, as well as identify and develop new targets and chimeric antigen receptors (CARs). The main function of this role is to develop cell-based assays for T cell characterization, proliferation, and function, and to coordinate new research projects to overcome various obstacles within the tumor microenvironment.

Responsibilities:
•  Design/execute diverse immuno-assays to evaluate T-cell biology, including cell sorting (fluorescent and/or magnetic), multi-color flow cytometry, Luminex, cytokine profiling, etc.
•  Analyze experimental data and present internally to identify promising new CAR candidates for subsequent development.
•  Work collaboratively and cross-functionally for preclinical development in animal models of cancer.

Requirements:
•  PhD in Immunology, Cell/Molecular Biology, or related field.
•  1-5 years of relevant experience in immunology, I/O, or autoimmunity.
•  Experience with cell culture techniques, sorting primary human and/or animal T cells, and developing cell-based immuno-assays and T cell functional assays.
•  Applied expertise in T cell therapeutics is a plus, either in academia or industry.
 

Formal descriptions can be supplied for interested candidates.

Must be authorized to work in the U.S. indefinitely to be considered.

All resumes will be kept strictly confidential until you choose to pursue a specific opportunity with one of our clients.