Discovery / Research

Veterinary Pathologist Direct Hire MA

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Job ID: 16052 Direct Hire MA

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Our client is a medical device and pharmaceutical Contract Research Organization in the suburbs of Boston.  They are seeking a Veterinary Pathologist to join their Pathology team and work with clients to design studies, analyze and present data internally and to the study sponsors, and support implementation & optimization of adjunct technologies and services (fluorescent microscopy, in-house clinical pathology and clinical chemistry).

Responsibilities include but are not limited to;
•  Function as Study Director or Principal Investigator, as required, and communicate with study sponsors to design studies and report pathological and/or study related findings
•  Evaluation of tissue responses via gross inspection and microscopy and supervising necropsy procedures
•  Peer review of pathology working group and serve as a consultant in pathology-related issues 

Formal descriptions can be supplied for interested candidates. 

Qualified candidates will have a DVM or equivalent degree and ACVP certification. Industry experience is not required but welcome.  More experienced candidates are also welcome.  

Must be authorized to work in the US indefinitely to be considered and must be commutable to the suburbs of Boston/Cambridge area or able to relocate with limited assistance.  

All resumes will be kept strictly confidential until you choose to pursue a specific opportunity with one of our clients.

Principal Computational Scientist Direct Hire MA

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Job ID: 15995 Direct Hire MA

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Our Global Biologics client is looking to add a Principal Computational Scientist to their team to support their Immuno-Oncology programs here in Cambridge, MA!  It is an exciting time to be a part of the Discovery teams!  This role will help with designing experiments, manage data, and use advanced statistical, machine learning, as well as computational techniques to discover new targets either to stop the growth of cancer or re-awaken the immune system to eradicate the cancer. Furthermore, the Data Scientist will collaborate with Early Development teams to guide the development of molecules against those targets with data-driven biomarker plans.  Other responsibilities include but not limited to:

  • Work with project teams to define scientific questions that can be addressed with an appropriately powered experimental designs
  • Supply any computational, statistical, machine learning, or modeling capability needed to synthesize from this design actionable recommendations relative to the team’s question
  • In collaboration with project teams, propose analysis strategies for target discovery, using methods based for instance on differential expression, co-regulation, correlated amplification, recurrent alterations, etc.; in so doing, also help devise statistical metrics for deciding significance, and ranking schemes for integrating data from many sources
  • Identify targets and biological contexts (e.g., T or B-cell repertoire, immune phenotypes, copy number, mutational, or expression signatures) in which therapies are likely to be beneficial by mining immune, genetic, genomic or screening data
  • Identify from patient and model system databases the epidemiology of these biological contexts and targets
  • Develop biomarker plans (e.g., selection, PD, efficacy) in collaboration with project teams
  • Manage and develop group of one or more associates and/ or contractors

Requirements:

  • Ph.D. in a computational, statistical, biophysics, or bioinformatics related fields.
  • A minimum of 8+ years project-based work in computational application to biology related fields, preferably Immuno-Oncology
  • Statistical programming skills like SAS/S-plus, R/Bioconductor and pipeline pilot or equivalents
  • Excellent understanding of immunology and hands-on research experience investigating complex lymphoid and/or myeloid cell subsets
  • First-hand multi-parametric data mining experience for target identification and biomarker discovery. For example, multivariate analysis; dimensionality reduction methods; parametric and non-parametric statistical methods; Bayesian statistics; pattern recognition or classification methods.
  • First-hand experience at integrating publicly or commercially available genetic, genomic, and immune datasets with novel experimental data to identify testable hypotheses
  • Developed communication and presentation skills and a successful track record of collaborating with cross-functional project teams
  • Demonstrated ability to lead projects of moderate scope, mapping-out critical path, milestones and timelines, as well as manage customer expectations with minimal supervision

Associate Scientist, CAR-T Direct Hire MA

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Job ID: 15365 Direct Hire MA

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Our client is a highly-regarded cell/gene therapy company in the greater Boston area and they are seeking an experienced, highly-motivated Immuno-Oncology Associate Scientist to join their research and discovery team to work on next-generation CAR-T therapies in oncology! You will collaborate with and help other teammates troubleshoot assays, as well as identify and develop new targets and chimeric antigen receptors (CARs). The main function of this role is to support cell-based assays for T cell characterization, proliferation, and function, and to coordinate new research projects to overcome various obstacles within the tumor microenvironment.

Responsibilities:
•  Support diverse immunological assays to evaluate T-cell biology, including cell sorting (fluorescent and/or magnetic), multi-color flow cytometry, Luminex, cytokine profiling, etc.
•  Analyze experimental and flow cytometry data to identify promising new CAR candidates for subsequent development.
•  Work collaboratively/cross-functionally and use viral vectors to genetically modify T lymphocytes.?

Requirements:

•  BS/MS in Immunology, Cell/Molecular Biology, or related field.
•  At least 2+ years of relevant experience in immunology, I/O, or cancer biology.
•  Experience with cell culture techniques, sorting primary human and/or animal T cells, and developing cell-based immuno-assays and T cell functional assays.
•  Applied expertise in T cell therapeutics is a plus, especially in industry.

Formal descriptions can be supplied for interested candidates.

Must be authorized to work in the U.S. indefinitely to be considered.

All resumes will be kept strictly confidential until you choose to pursue a specific opportunity with one of our clients.

CAR-T Scientist Direct Hire MA

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Job ID: 15301 Direct Hire MA

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Our client is a highly-regarded cell/gene therapy company in the greater Boston area and they are seeking an experienced, highly-motivated Immuno-Oncology Scientist to join their research and discovery team to work on next-generation CAR-T therapies in oncology! You will collaborate with and help other teammates troubleshoot assays, as well as identify and develop new targets and chimeric antigen receptors (CARs). The main function of this role is to develop cell-based assays for T cell characterization, proliferation, and function, and to coordinate new research projects to overcome various obstacles within the tumor microenvironment.

Responsibilities:
•  Design/execute diverse immuno-assays to evaluate T-cell biology, including cell sorting (fluorescent and/or magnetic), multi-color flow cytometry, Luminex, cytokine profiling, etc.
•  Analyze experimental data and present internally to identify promising new CAR candidates for subsequent development.
•  Work collaboratively and cross-functionally for preclinical development in animal models of cancer.

Requirements:
•  PhD in Immunology, Cell/Molecular Biology, or related field.
•  1-5 years of relevant experience in immunology, I/O, or autoimmunity.
•  Experience with cell culture techniques, sorting primary human and/or animal T cells, and developing cell-based immuno-assays and T cell functional assays.
•  Applied expertise in T cell therapeutics is a plus, either in academia or industry.
 

Formal descriptions can be supplied for interested candidates.

Must be authorized to work in the U.S. indefinitely to be considered.

All resumes will be kept strictly confidential until you choose to pursue a specific opportunity with one of our clients.